A neutralizing antibody directed against IL-8 showed a trend toward reduced MSC chemotaxis from 604+/−147.7 MSCs to 374+/−125.9, however this was not statistically significant ( Figure 5F ).
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Macrophage-associated mesenchymal stem cells assume an activated, migratory, pro-inflammatory phenotype with increased IL-6 and CXCL10 secretion.
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