A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes.

PLoS Genet · 2012 · PMC3320604 · PMID 22496669

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a clear trendno p-value reported

While there is a clear trend for SNPs that decrease the RE1 motif score to also strongly decrease their binding affinity, this relationship is not strong for SNPs that increase binding affinity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.