Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

PLoS One · 2012 · PMC3320873 · PMID 22493730

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a clear trendno p-value reported

There was a clear trend towards better clinical outcomes at the dose of 70 mg QD with half of patients showing significant histological improvement at week 12.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.