Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators?

Adv Pharmacol Sci · 2012 · PMC3321276 · PMID 22536226

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approached significanceno p-value reported

After 28-day diazepam treatment, tolerance to the depressant effect of diazepam on cerebral glucose occurred in the mamillary body, subiculum, and caudate nucleus, whereas changes in the frontal cortex approached significance.

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