Barely Significant
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The immune response to melanoma is limited by thymic selection of self-antigens.

PLoS One · 2012 · PMC3323626 · PMID 22506061

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Higher responses in AIRE −/− mice were observed consistently in several experiments however, due to the wide variations seen among AIRE −/− mice, the difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.