Whereas, one month following last mating, GluA2 was significantly increased in S/I ratio ( Figure 2H ; p = 0.046) accompanied with a statistical trend towards an increase in surface expression ( Figure 2B ; p = 0.055) in sexually experienced animals compared to naïve controls.
In terms of increased GluA1 surface expression, the present data indicate a modest increase in GluA1 receptors at the membrane surface that failed to reach statistical significance at 1 month after sex experience, and thus suggesting that GluA1 surface expression may require longer abstinence periods for further up-regulation, similar to the changes induced by cocaine after 5 weeks of abstinence [31] .