Despite the fact that some comparisons did not reach statistical significance, these findings confirm previous reports of a pro-inflammatory profile of MΦ IFN-γ versus a more neutral to anti-inflammatory profile for MΦ IL-4 and MΦ IL-10 upon TLR stimulation [5] , [7] , [13] , [15] .
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Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.
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