A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF.

Front Immunol · 2011 · PMC3342026 · PMID 22566797

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showed a trendno p-value reported

Analysis of CD25 + and CD25 − B1a immunoglobulins showed a trend toward more N-less (and thus more germline like) sequences in the former (unpublished observations); however, this did not reach the level of significance and it will be necessary to examine antigen recognition rather than antibody structure to elucidate the origin of B1a continual signaling and CD25 expression.

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