Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors.

Finally, in the comparison between the non-oncocytic tumor variants and the general cancer variants, there was a nominally significant difference only in the Complex V genes (though this was not significant after correction for multiple testing).

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For two genes there were highly significant differences in the variation frequencies in the oncocytic and general cancer categories.

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