Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study.

During the 2005–2010 period there was a highly significant mean quarterly reduction in deaths involving co-proxamol alone that received a suicide (including open) verdict (−21 [95% CI −34 to −8]), and similarly when accidental deaths were included (−25 [95% CI −38 to −12]).

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There was an overall reduction in poisoning deaths receiving suicide or open verdicts in England and Wales in 2005–2010, although this did not reach statistical significance.

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