Extent, causes, and consequences of small RNA expression variation in human adipose tissue.

While on the whole, none of the cis -SNPs were genome-wide significant in the GWAS data, they were significantly enriched for nominally significant (p<0.05) SNPs in the BMI GWAS results ( [65] , binomial p = 0.007), indicating either their pleiotropic effect, or metabolic trait regulation through small RNA expression levels. rs2440129 was nominally significant in the BMI GWAS lookup [65] , while mir-195-3p was significantly associated with both rs2440129 in cis (FDR<5%, p<2.4×10 −5 ), as well as BMI (FDR<5%, p<3.9×10 −3 ) and PTFM (FDR<5%, p<4.1×10 −3 ), suggesting a mechanism for the rs2440129 association.

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