2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

Ifit1 −/− mice infected with WNV-WT showed a trend towards increased mortality, although this failed to attain statistical significance (52% survival for Ifit1 −/− mice compared to 75% survival for wild type mice, P = 0.1; Figure 1A ); thus, in contrast to previous results with other ISGs [30] , [31] , an absence of Ifit1 did not markedly enhance pathogenesis of the virulent North American WNV strain.

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