Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.

PLoS One · 2012 · PMC3351460 · PMID 22615794

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a clear trendno p-value reported

We found a clear trend where increased number of PTO bonds results in lower survival of cells 48 hrs after oligo transfection ( Figure 3a ), consistent with PTOs being toxic.

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