Typical and atypical antipsychotic drugs increase extracellular histamine levels in the rat medial prefrontal cortex: contribution of histamine h(1) receptor blockade.

Risperidone (1 mg/kg) induced a slight increase in HA release, however, this failed to reach statistical significance [ t (8) = 1.162; NS].

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When we examined the relationship between affinity at histamine H 1 receptors and mPFC histamine efflux we found a highly significant correlation which suggests that antagonism of histamine H 1 receptors may mediate the increase in histaminergic neuronal activity following antipsychotic treatment.

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