Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.

In contrast, the ER/MT enriched fractions (#7 and #8) that display low detectable PrP res levels, contained high infectivity levels similar to the lipid raft enriched fractions, with the discrepancy at fraction #8 highly significant (p < 0.001; two way ANOVA).

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In fact, there was a clear trend for increased PrP res propagation by recipient cells after infection with M1000 diluted in subcellular fractions compared to the lysis buffer only control, independent of whether the fractions contained PrP C .

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