Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells.

PLoS One · 2012 · PMC3356265 · PMID 22624003

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hugely significantno p-value reported

In studies assessing the effects of candidate microbial and endogenous immunomodulators, LPS contamination of sample preparations has proven to be a hugely significant problem, often resulting in misleading and inaccurate conclusions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.