Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study.

PLoS One · 2012 · PMC3358256 · PMID 22629410

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp<0.0001actually significant

Methylation level difference was highly significant (p<0.0001) for all CpGs in LINE-1, Alu repeats and in p16, APC SN1, ACIN1 SN1 and SN3, BCL2, CD44, TNFRSF10C.

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a strong trendno p-value reported

Although this pilot study indicates a strong trend for a possible use of whole blood DNA methylation as marker for presence of pancreatic adenocarcinoma and its association with the progression of the disease, special care should be taken before such an approach is transferred to a clinical setup for the following reasons: 1) The relatively small p

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.