Although VEGF level was also decreased in an ischaemic hindlimb of donepezil-treated mice, the difference of VEGF level between control and donepezil-treated mice showed a borderline significance.
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qRT–PCR also showed a trend towards reduction of CD3ε (T-lymphocytes) and F4/80 (macrophages) mRNA in the ischaemic hindlimb of the donepezil-treated mice compared with that of control mice.