Role of c-Jun N-terminal protein kinase 1/2 (JNK1/2) in macrophage-mediated MMP-9 production in response to Moraxella catarrhalis lipooligosaccharide (LOS).

At 6 hours following LOS treatment, we detected relatively little amount of MMP-9 in culture supernatants but it was readily detected at12 hours, reaching its peak at 24 hours with a slight but probably not significant decrease at 48 hours ( Fig. 1B ).

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