Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice.

Assay of SHP mRNA ( Figure 4C ) showed that the reduced levels of SHP in the Slc10a2 −/− mice were indeed normalized following the SR diet, although the reduction of SHP seen in the Slc10a2 −/− mice in this experiment did not reach statistical significance.

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