Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.

Using this method, we found that the frequency of aa substitutions associated with NA treatment resistance was not significantly different from that of the remaining aa changes; the differences approached significance only in patient 4 ( P = 0.09) ( Table 1 ).

also in 8,237 other papers