nominally significantp = 0.04
At rs1477798 in 15q22.31 which showed evidence of linkage in clinic-based, larger families, a nominally significant case-control association was observed (OR 1.16, p = 0.04) which was modestly strengthened for cases with CRC family history (OR 1.24, p = 0.03); however, no significant difference in risk by family history was observed and associations were far from genome-wide significant.