Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase.

In 8226 cells, treatment with IL-6 (2.5 or 50 ng/ml) for 4 h resulted in a decrease in total intracellular GSH, whereas IL-6 treatment for 10 h or 24 h showed a trend towards an overall increase in the steady-state levels of GSH ( Figure 3 C).

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