Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo.

In the higher dose of NMDA, the protection afforded by the BMP4 was more variable (940.8±398.9 Brn3+ cells/mm 2 ), and did not reach statistical significance; however, the neuroprotective effect of BMP4 was statistically significant in the 10 mM treatment group (1107.0±167.7 Brn3+ cells/mm 2 ) ( Figure 6B ).

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