β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.

EMBO Mol Med · 2012 · PMC3376850 · PMID 22170863

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Even this 10-fold higher GSI dose did not correct the memory deficit of Danish mice, and GSI-treated WT mice showed a trend, though not statistically significant, towards memory impairment ( Fig 4B ).

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