Furthermore, we found a highly significant correlation between the expression of NCAM and that of the individual FGFR genes in a published cDNA microarray dataset of 255 EOC samples (Crijns et al, 2009 ; Fig S2 of Supporting Information).
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The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling.
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NCAM expression was also more frequent in tumours at advanced International Federation of Gynecology and Obstetrics (FIGO) stages as compared to early stages, although the correlation did not reach statistical significance ( Table 1 ).