Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

A highly significant statistical interaction term between PNPLA3 genotype and severe obesity status was observed in determining risk of type 2 diabetes (P = 0.002).

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The association with ALT levels was present in both groups (data not shown), but the association with serum triglycerides was only found in the severely obese (BMI≥35) group (II: 225±131, IM: 208±132, MM: 191±131 mg/dL, P = 0.003) and not in those with BMI<35 (II: 190±122, IM: 184±117, MM: 184±120 mg/dL, P = 0.219), although the interaction term did not reach statistical significance (P = 0.18).

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