Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Nat Genet · 2011 · PMC3378381 · PMID 21983784

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 1e-16actually significant

Follow up genotyping of 70 rare and low-frequency protein-altering variants (MAF ~ .001-.05) in nine independent case-control series (16054 CD patients, 12153 UC patients, 17575 healthy controls) identifies four additional independent risk factors in NOD2 , two additional protective variants in IL23R , a highly significant association to a novel, protective splice variant in CARD9 ( p < 1e-16, OR ~ 0.29), as well as additional associations to coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19 .

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nominally significantno p-value reported

In addition, we report additional protective variants at IL23R , and identify an excess of additional nominally significant variants in MUC19 , PTPN22 , and C1orf106 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.