Interestingly, all other parameters analyzed were significantly decreased in comparison to control animals (average of the parameters variation of 17.3%, ranging from 8.7% to 31.4%), with the exception of LDH, uric acid and transaminases ratio, which, despite being also decreased in the DOX-treated group, did not reach statistical significance when compared with the saline group.
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Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific.
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