Adaptive evolution and functional constraint at TLR4 during the secondary aquatic adaptation and diversification of cetaceans.

The ω values along three branches were found to be greater than 1 with nearly significant statistical support ( p = 0.0595): branch a leading to the last common ancestor of cetaceans and hippos (ω = 4.59), branch b leading to oceanic dolphins (ω = 1.33), and branch c leading to the last common ancestor of Phocoenidae (porpoises) + Monodontidae (white whales) (ω = 1.34) (Figure 1 ).

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