Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.

PLoS One · 2012 · PMC3386276 · PMID 22761780

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did not reach statistical significanceno p-value reported

Systolic blood pressure (SBP) of the carvedilol group and the ivabradine group slightly increased compared to the myocarditis group on days 7 and 14, but this effect did not reach statistical significance, and SBP of the ivabradine group did not differ compared to the carvedilol group.

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highly significantno p-value reported

The primary composite endpoint of cardiovascular death or hospital admission for worsening heart failure was significantly reduced, largely due to a highly significant reduction in hospitalization from heart failure.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.