Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis.

Arthritis Res Ther · 2012 · PMC3392823 · PMID 22309893

Europe PMC DOI

hedged sentences

0.0040

closest p · 0.1× alpha

0.0040

boldest claim

The sentences

highly significantP = 0.004actually significant

Further, we have confirmed this association with a meta-analysis that includes seven published patient cohorts; while the association is relatively modest and somewhat less than that reported for SLE (OR 1.47, 95% confidence interval 1.13 to 1.92), it is highly significant ( P = 0.004).

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failed to reach statistical significanceno p-value reported

This meta-analysis confirms that low FCGR3B CN is a risk factor for RA (OR 1.47, 95% confidence interval 1.13 to 1.92, P = 0.004, random-effects estimate), even though many individual studies failed to reach statistical significance (Figure 2 ).

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