HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.

HPV 38 E6 expressing HT1080 cells were more significantly more sensitive to cisplatin, but the increased sensitivity did not reach statistical significance for mitomycin C exposure ( Figure 4C and D ). β HPV E6 expression attenuates ATR expression by promoting p300 degradation Having shown the increased persistence of thymine dimers and elevated UVB induced phospho H2AX levels to be dependent on HPV E6 promoting p300 degradation, we wanted to further elucidate the mechanism of attenuated UVB damage repair in HPV 5 and 8 E6 expressing cells. p300 interacts with ATR, a member of the PI3 kinase family, and is necessary for activation of ATR in response to hydroxyurea [47] .

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