The Function of SPARC as a Mediator of Fibrosis.

Open Rheumatol J · 2012 · PMC3395844 · PMID 22802913

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did not reach statistical significanceno p-value reported

In addition to the robust reduction in collagen synthesis, the authors also reported slight changes in levels of TGF-β receptor1 and smad3, a downstream signaling molecule in the TGF-β pathway, in SPARC siRNA treated cells, although changes in the levels of these proteins in siRNA-treated cells did not reach statistical significance [ 56 ].

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