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Roflumilast-N-oxide induces surfactant protein expression in human alveolar epithelial cells type II.

PLoS One · 2012 · PMC3398032 · PMID 22815690

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Although the highest concentration of roflumilast-N-oxide doubles SP-A1 expression of AEC-II, the observed increase did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.