Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.

However, while mice on a normal diet showed a trend for a negative gene dose-dependent effect on fasting blood glucose, glucose tolerance and cholesterol (with Dp11(1)/+ mice showing a significant reduction in fasting blood glucose, when compared to WT animals; Fig 7B ), high-fat diet treated animals showed a significant negative gene dose-dependent effect on glucose tolerance and cholesterol (glucose tolerance: F [2,65] = 3.196, p = 0.04; cholesterol: F [2,79] = 3.9, p = 0.02; Fig 7C and D and Fig S3 of Supporting Information).

also in 53,322 other papers