Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells.

57 , 65 Regulation of the 14q32 miRNA cluster As more than 85% of the miRNAs expressed in this region showed a trend for downregulation in schizophrenia, it is reasonable to suggest that these molecules may be co-regulated by a shared mechanism associated with the disorder.

also in 53,322 other papers

62 This is detectable throughout the developing mouse embryo and the placenta, is enriched in the brain in adult mice 29 , 57 , 62 , 78 and may be significant for the development of higher brain functions in eutherian mammals. 79 The neural function of this cluster is supported by recent research suggesting that coordinated expression of these miRNA, including miR-134 and miR-329, is important for brain function and development.

also in 13,097 other papers