When analyzed by two-way repeat measures ANOVA, this trend did not reach statistical significance ( P = 0.32) without pooling of replicate groups (described above for A–P and A–M), though there was a significant increase in avidity over time after final vaccination across all groups ( P < 0.0001).
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Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1.
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