Barely Significant
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Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine.

PLoS One · 2012 · PMC3405106 · PMID 22855691

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Serum IgG1 production from VLP and MB (25 μg), VLP and CT, and VLP alone groups were all similarly elevated in comparison to PBS group, but did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.