UNG shapes the specificity of AID-induced somatic hypermutation.

J Exp Med · 2012 · PMC3405504 · PMID 22665573

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showed a trendno p-value reported

In addition, we found that of all sixteen WR C Y/R G YW hotspots only AG C T, A G CA, and A G CT showed a trend to accumulate transversion mutations when UNG is overexpressed ( Fig. 4 B ), suggesting that UNG preferentially promotes the error-prone processing of uracils when they are in these particular contexts.

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