Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

Although we found marginal significance between two SNPs, rs7013278 and rs7014346 (HR = 2.20, P = 0.01 and HR = 1.96, P = 0.03 respectively), with inferior CRC survival by multivariate regression analysis, none of these variants showed study-wide association with survival after correction for multiple testing.

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In multivariate analysis, patients homozygous for the CRC risk allele of rs7013278 or rs7014346 (both at 8 q24) were only nominally significant for poorer overall survival compared to patients homozygous for the protective allele (hazard ratio = 2.20 and 1.96, respectively; P <0.05).

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