Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice.

Lipid accumulation in liver Although the difference in hepatic cholesterol between animals fed the control and HF–HS diets did not reach statistical significance, the HF–HS diet elevated hepatic triglyceride levels by 135% ( P < 0.001) at week 2 and 42% ( P < 0.05) at week 4 (Figure 4 A).

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