Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α.

One study used perfused rat livers after PH and showed a trend toward decreased de novo lipogenesis as compared with controls. 28 Furthermore, mitogen stimulation of cultured primary rat hepatocytes leads to decreased lipogenesis. 33 Hepatic lipid metabolism is likely to be regulated by numerous factors in the regenerating liver, 27 , 31 and our data indicate that the effect of cyclin D1 is to diminish lipogenesis.

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