Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile.

Interestingly, there was actually an increasing trend in 28-d mortality from February 1998 through January 2000 that did not reach statistical significance (odds ratio [OR] = 1.02 per year, p = 0.3).

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In contrast, for neutrophil counts we found that an increasing trend from February 1998 changing to a decreasing trend would have been detected in December 2001, with some uncertainty around the exact time of change (April 1999–October 2000), most likely time being January 2000.

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