p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy.

Int J Otolaryngol · 2012 · PMC3409529 · PMID 22888357

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a trend towards significanceno p-value reported

p16 and cyclin D1 were also significantly associated with LRC, while HIF-1 α (nuclear) and EGFR demonstrated a trend towards significance with LRC as an endpoint.

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showed a trendno p-value reported

Retrospective subset analyses of TROG 02.02 showed a trend for improved outcomes of patients with p16− tumors treated with cisplatin and the hypoxic cell sensitizer tirapazamine compared to cisplatin alone [ 16 ].

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