Expression of Ntf5 appeared to increase gradually between E14.5 and P2, although this change did not reach statistical significance (26.0 ± 5.8 pmol/nmol rising to 89.6 ± 46.9 pmol/nmol Gapdh ; P = 0.5; Fig. 1B ), and no discernable change was observed in the expression of Bdnf over the gestational range examined.
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Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development.
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In summary, we have identified significant differences in the expression of the genes encoding the TrkB ligands NT4 and BDNF both within and between the developing ovaries of humans and mice, and these variations suggest that the relative levels of TrkB ligands may be significant in determining their effects.