Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.

After correcting for multiple testing, none of these pairs showed nominally significant evidence of interaction in the WTCCC data ( File S1 Supporting Table 2) for the SNP pairs from Analysis 1 (p min = 0.0041; α≈0.05/47≈0.0011), Analysis 2 (p min = 0.0392; α≈0.05/49≈0.001), Analysis 3a (p min = 0.006; α≈0.05/45≈0.001) or Analysis 3b (p min = 0.012; α≈0.05/50≈0.001).

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We performed pair-wise SNP interaction testing in three Analyses, first requiring that both potentially interacting SNPs have highly significant effects on CHD risk or CV risk factors (Analysis 1), then relaxing this requirement for one of the SNPs, requiring that it be at least moderately associated with MI (p≤0.001; Analysis 2), and finally requiring that both SNPs have only moderate (p≤0.001) or weak (p≤0.01) marginal association with MI (Analyses 3a and 3b, respectively).

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