Proof of concept in cardiovascular risk: the paradoxical findings in blood pressure and lipid abnormalities.

7 Niacin was the only agent tested in the Coronary Drug Project that showed a trend for efficacy. 8 A meta-analysis of 22 trials showed that old lipid-lowering agents failed to prevent cardiovascular events. 9 Moreover, older lipid drugs were associated with higher risk for mortality by accidents and violence, 10 leading to the discredit of the beneficial effects of lipid-lowering

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