Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure.

Lipid hydroperoxidation in plantaris muscle were similar between groups at the 3 rd month, progressed to a strong trend toward elevation in 5 month-old α 2A /α 2C ARKO mice and culminated in significantly increased lipid hydroperoxidation in 7 mo-old α 2A /α 2C ARKO mice when compared with age-matched WT ( Figure 2B ).

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