The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.

Nat Immunol · 2012 · PMC3411897 · PMID 22772404

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Although the total numbers of GFP + thymocytes were unaffected, retroviral expression of Gfi1 in Lyl1 −/− progenitors permitted lymphoid development and showed a trend towards increased frequencies of T-lineage cells compared to GFP -transduced controls (p=0.1) suggesting that Gfi1 is a critical target of Lyl1 at the ETP stage, enabling thymic T cell lineage development.

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